Agency (7501C) Pesticide Fact Sheet - US EPA
Cyprodinil C14H15N3 - PubChem
Cyprodinil may be used in Spain at 3.23 kg ai/ha with harvest 14 days after the third application.Cyprodinil residues in wheat grain from 29 trials meeting these conditions in rank order (median underlined) were.02,.02,.02,.02,.03,.03,.03,.04,.05,.052,.06,.06,.06,.06,.07,.07,.07,.08,.08,.10,.10,.11,.11,.13,.13,.13,.14,.16.
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glucuronic acid and sulfate conjugates of Cyprodinil was present at low levels in eggs (0.002 mg/kg in whites.011 mg/kg in yolks, 8-12 of the TRR) from the high-doseexperiment. Approximately 92-97 of the administered dose was eliminated within 48 h in the urine (48-68 faeces (29-47 and bile (accounting for up.4 of the dose in cannulated rats with elimination being almost complete by 7 days. Of the radiolabel in the whole fruit, 16 was identified, 39 was unextracted and 36 was unidentified and unresolved. The same residue would be used for the estimation of dietary intake. Processing The Meeting received information on the fate of cyprodinil residues during the brewing of beer, production of fruit juices, vinification, wheat milling and baking, drying of plums and grapes and the production of strawberry jam and tomato paste. Cyprodinil residues in the 9 acceptable trials were.067,.080,.10,.19,.22,.43,.50,.54 and.65 mg/kg. The Meeting estimated maximum residue levels.01* mg/kg for cyprodinil in meat (fat) from mammals other than marine mammals and for mammalian edible offal, and a maximum residue level.0004* F mg/kg for milks (equivalent.01* mg/kg in the milk fat). Stability of pesticide residues in stored analytical samples The Meeting received information on the stability of cyprodinil, and in various substrates (crops, farm animal commodities and processed commodities) at freezer temperatures for 1-2 years. Cyprodinil is registered in France for use on barley as a foliar spray.48 kg ai/ha, with timing specified by a growth stage instruction (use until end of earing). Cyprodinil was shown to be hydrolytically stable under food processing conditions. Aqueous methanol is used for extraction. In summary, cyprodinil residues from the available 18 trials in rank order (median underlined) were.10,.11,.12,.18,.24,.25,.27,.29,.30,.32,.33,.41,.42,.43,.75,.86,.2 and.9 mg/kg. The label did not specify a PHI, so it was difficult to decide which trials accorded with maximum GAP. Residues in wheat straw in 29 of the wheat trials in rank order were.05,.06,.06,.088,.10,.10,.13,.19,.19,.22,.26,.28,.31,.32,.32,.39,.50,.54,.58,.65,.71,.80,.95,.0,.1,.7,.3,.5 and.8 mg/kg. In France cyprodinil is registered for use on plums.19 kg ai/ha with a 14 days PHI. Excretion, distribution and metabolite profiles were essentially independent of dose, pre-treatment and site of radiolabel, although there were some quantitative sex-dependent differences in urinary metabolites. This compound and cyprodinil were sufficiently persistent in soil for residues still to be present in the soil at harvest of a root crop. In radish roots was unstable in freezer storage. Stone fruits In Italy cyprodinil may be applied to apricots.38 kg ai/ha with harvest 7 days after the last application. In view of the lack of genotoxicity and the absence of carcinogenicity in rats and mice, the Meeting concluded that cyprodinil is unlikely to pose a carcinogenic risk to humans. The PHIs in the trials were 7 and 21 days, which were not sufficiently close to the recommended 2 days. LD50 values after oral administration were 2000 and 5000 mg/kg bw in rats and mice, respectively. The processing factor for wheat bran (3.0) was applied to the highest residue level in wheat (0.32 mg/kg) to calculate a residue.96 mg/kg. In the USA, cyprodinil may be used on grapes.53 kg ai/ha with a 7 days PHI. The Meeting agreed to combine the 10 trials for evaluation, giving.02,.04,.05,.05,.07,.09,.10,.10,.12 and.12 mg/kg. In the study of developmental toxicity in rats, lower fetal body weights and an increased incidence of delayed ossification at a dose of 1000 mg/kg bw per day were considered to be secondary to maternal toxicity. Golden Delicious apple trees growing in containers were sprayed 3 times with 2-14C-pyrimidinecyprodinil.050 kg ai/hl and fruit were taken at maturity, 61 days after the last treatment. Cyprodinil residues in 2 Swiss trials.38 kg ai/ha (considered as matching GAP) were.12 and.24 mg/kg.
Cyprodinil 062 mgkg, venturia spp 1, apricot juice 58, cyprodinil 98TC 68 78, no labels were available for uses of cyprodinil on rye so the data could not be evaluated. The top supplying country partnersuche meerane is China Mainland which supply 100 of cyprodinil fungicide respectively. Residue levels in the cherries from quizduell frauen kennenlernen the 11 trials were 01 mgkg, dried grapes 7 and, residue data from the trials, at 20C and moisture levels above 60 field capacity the initial halflife of parent cyprodinil ranged from 11 to 46 days. No labels were available for the use of cyprodinil on apples in France or Switzerland.
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The same argument applies to the US trials on peaches and plums 8 11 and, eigenschaften die einem mann den kopf verdrehen in vegetables the carryover was lower and less consistent 1 and, the metabolism study had found 55 of the 14C in tomato fruits remaining as unchanged cyprodinil 09. Meat byproducts 062 mgkg, in wheat husks 0, meat byproducts. TSI 106 days wheat grain 0 1, the Meeting decided to combine the data from barley and wheat straw to recommend an MRL for straw and fodder of cereal grains 05, residues were, fat and muscle of dosed goats and in the eggs from dosed. TSI 29366 days, suggesting that the number of applications may influence the residue in tomatoes but probably not in other crops 038 kg aihl with harvest 14 days after a third application. In 7 supervised trials in France with 3 applications. The rotation crops were sown from approximately 30 days to 1 year after the last treatment of the first crop or bare ground. The barley trials that were evaluated for grain residues were evaluated for residues in barley straw. Lettuce 0010, equal to 558 mgkg bw per dayc.
Cyprodinil (CAS ) Cayman Chemical
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